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University of Pittsburgh

Center Director

David Lacomis, MD

David Lacomis, MD

Dr. Lacomis is a Professor of Neurology and Pathology as well as Chief, Division of Neuromuscular Diseases. He directs the MDA-ALS Center and multidisciplinary clinic, co-directs the electromyography laboratory, and is in charge of the muscle and nerve pathology service. Dr. Lacomis has been named annually among the “Top Doctors” by Pittsburgh magazine, and in both “Best Doctors” and “America’s Top Doctors” nationally. He lectures extensively and is a contributing author for numerous medical journals and books regarding his major clinical interests of ALS, myasthenia gravis, and muscle diseases. Dr. Lacomis is the site Principal Investigator (PI) in the following studies: (1) A Phase IIb study of tirasemtiv in ALS (2) Diaphragm pacing vs best medical care in ALS (3) Discovery and validation of ALS biomarkers. He was the site PI for recently completed studies of ceftriaxone in ALS as well as a study assessing use of BiPAP and an epidemiology study in ALS. He is also a participant in the PA ALS Registry. With Drs. Carlisle and Friedlander, he is helping to generate motor neurons from skin stem cells of ALS patients. He also serves as the Director of the Clinical Neurophysiology fellowship, teaching and mentoring clinical fellows, medical students and house staff from Neurology and Pathology. He serves on the Clinical Neurophysiology Examination Committee for the American Board of Psychiatry and Neurology. Dr. Lacomis is a member of the editorial board for the Journal of Clinical Neuromuscular Diseases and two scientific advisory committees. See Publications

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